Asian American women are getting lung cancer despite never smoking. It’s baffling scientists and leading to more research.


It was fall 2021, and Aurora Lucas had a stubborn cough and chest pain. However, her doctors dismissed the symptoms, telling her to drink hot water and honey.

After three months of hospital visits, Lucas was diagnosed with stage 3 lung cancer at 28 years old, despite never having smoked. Lucas, who is Filipina American, represents a concerning trend for researchers.

According to a California study, lung cancer rates are dropping for every group except nonsmoking Asian American women — for whom they’re actually increasing by 2% per year.

While lung cancer is traditionally associated with cigarettes, as many as 20% of U.S. cases happen in never-smokers every year. Among Asian American women who have lung cancer, more than 50% have never smoked. And for Chinese and Indian American women who have lung cancer, the nonsmoking percentage rises to 80% to 90%.

Scientists are baffled by this pattern, and it has led to a recent surge of research. In two ongoing blockbuster studies at the University of California, San Francisco, and New York University, they’ve been searching for reasons why Asian American women are at especially high risk and for ways to catch their tumors earlier.

“It’s such a high rate; there has to be an explanation there,” Lucas said.

In May, the NYU researchers shared preliminary data at the American Society of Clinical Oncology conference showing that lung cancer screening in nonsmoking Asian American women works as well, if not better, than screening elderly, mostly white smokers.

Now, doctors are raising the alarm about increasing numbers of lung cancer cases in this community and working to reform the screening guidelines to better include Asian American women.

“As an Asian woman, I was taught to be quiet,” Lucas said. “I had a high respect for doctors and medical staff, so I would never really question what they were telling me,” even when they didn’t understand what was wrong.

Understanding the risk factors

UCSF epidemiologist Scarlett Gomez was born in Taiwan before she immigrated to the U.S. at 7 years old, her parents working in Chinese restaurants in Washington state. But that also meant they were continuously, unknowingly exposed to toxic cooking oil fumes.

“Like many immigrant families, my parents were working in industries that were beneath their training,” Gomez said. “That was the job that they had to do to make it here.”

To date, studies of female nonsmokers in Asia have identified risk factors such as cooking oil fumes, secondhand smoke, air pollution and indoor heating with coal, but no research has focused on Asian American women, Gomez said.

Nevertheless, there’s probably some overlap. For example, a 2019 study found that Asian Americans breathe in 73% more tiny pollution particles than white Americans, most likely because of greater exposure to construction, industry and vehicle emissions where they live.

Air pollution may also lead to genetic changes such that Asian patients have some of the highest rates of the cancer-causing epidermal growth factor receptor mutation, which leads healthy cells to divide uncontrollably and grow into tumors.

“I hope we’ll see more studies to address these unusual, emerging disparities among Asian Americans that we previously haven’t paid attention to,” Gomez said.

Given the lack of clarity, Gomez and Iona Cheng, a fellow epidemiologist at UCSF, launched the Female Asian Never Smokers, or FANS, study in 2021. It’s a case-control study, in which the team is studying nonsmoking Asian American women who were either recently diagnosed with lung cancer (the cases) or who never had lung cancer (the controls).

Although the two groups are matched in terms of ethnicity and age, the researchers hope to find some differences in genetics, as assessed by saliva samples, and environmental exposure, determined through surveys asking about people’s pasts. “The whole goal of this study is to identify risk factors,” Gomez said.

However, FANS can’t show cause-and-effect relationships, said Dr. Latha Palaniappan, a physician at Stanford University, who isn’t involved with the study.

For one, women with lung cancer may be more likely to remember their exposure to chemicals and toxins than women without lung cancer because they’ve been thinking harder about their risk factors — something known as “recall bias.”

Still, Palaniappan emphasized FANS’ groundbreaking nature, because “we can definitely understand associations, and the study can give us an idea for more rigorous analyses going forward.”

Making lung cancer screening more equitable

At NYU, Dr. Elaine Shum, an oncologist, has seen dozens of nonsmoking Asian American women with lung cancer, many with stage 4 disease. And it’s always frustrating: Lung cancer screening, via the low-dose CT scan, could have helped those women find their tumors earlier, at more treatable stages.

But insurance plans typically cover screening only for people ages 50 to 80 with heavy smoking histories — all but excluding Asian American women. And the recommendations were based on the National Lung Screening Trial, a clinical trial of 53,000 elderly smokers, over 90% of whom were white.

So Shum started her own clinical trial in 2021, giving lung cancer screening to 1,000 never-smoking Asian American women. Her initial results, which she presented at a major cancer conference, showed that Asian women had a higher lung cancer detection rate than the original national trial — 1.5% versus 1%. “Based on this preliminary data and other ongoing efforts, ​​Asian women do represent another high-risk population that warrants screening,” Shum said.

Palaniappan, who is also not affiliated with Shum’s trial, tends to agree: “It’s extraordinary that screening in this population yielded a similar incidence of lung cancer” to the original trial. But Palaniappan also cautioned that better inclusion of Asian American women in the screening guidelines is still a long way off, with many more studies needed to confirm and build on Shum’s findings. “We’re just at the beginning,” she said.

When Aurora Lucas was diagnosed with lung cancer, she was in the second year of her Ph.D. program, simultaneously working as a special education teacher in Chicago. (Taylor Glasscock for NBC News)

When Aurora Lucas was diagnosed with lung cancer, she was in the second year of her Ph.D. program, simultaneously working as a special education teacher in Chicago. (Taylor Glasscock for NBC News)

“There is hope; there’s a lot of progress in the lung cancer world,” says Lucas. “I can’t change the system because it’s broken, but I can help people advocate for themselves and learn.”

Why Asian American women have been left behind

When Lucas was diagnosed with lung cancer, she was in the second year of her Ph.D. program, simultaneously working as a special education teacher in Chicago. She had always thought of herself as healthy, so she initially chalked up the chest pain and coughing to stress. Now, she knows that Asian American women are at high risk for lung cancer, but she still doesn’t understand how her doctors didn’t.

While the research at UCSF and NYU is promising, it’s unclear why, in 2024, they are some of the first and only studies to focus on Asian American women with lung cancer.

On one level, it’s an awareness problem.

“Many Asian patients are very private and don’t want others to know about their diagnosis,” Shum said — often because they don’t want to be burdens to their friends and families or because they’re worried about the stigma of lung cancer. Perhaps as a result, the most common reaction Asian American women have when they hear about Shum’s work in lung cancer is “I didn’t even know this was an issue,” she said.

And that lack of awareness is aggravated by poor-quality data, according to Stella Yi, who co-leads the Innovations in Data Equity for All Laboratory at NYU. Namely, Asian Americans are often lumped into the “Other” category in surveys or in other overly broad groups like Asian Americans, Native Hawaiians, and Pacific Islanders, or AANHPI, that obscure their data.

Most national databases also collect information in English and occasionally Spanish, meaning many people never get the chance to be included. “So when you look at data reports where Asian Americans look healthier than everyone else, it’s because you’re only reaching the highest-income, highest-educated,” Yi said.

As a result, lung cancer cases among Asian American women are probably underreported, and the data reinforces racialized stereotypes. “Asian Americans are thought to be healthy; they’re the model minority,” Yi continued, referring to the myth that all Asians have high academic and economic achievement. “They’re doing tai chi in the park, so why would they be getting lung cancer? Why would they have health disparities?”

For scientists who want to disrupt that narrative, it can be incredibly difficult, because only 0.17% of the National Institutes of Health budget over 26 years was devoted to research on AANHPI. “We hear a lot of stories from patients with lung cancer whose primary care doctor said, ‘You don’t need this; you’re not at high risk,’” Shum said. With poor data and a lack of research among Asian American women, “lung cancer gets pushed to the side.”

That’s why Lucas thinks it took her three months for a doctor to take her symptoms seriously and make a diagnosis. “My doctors were in denial about the possibility of cancer,” she said, with the team fluttering from a sore throat to tuberculosis to the idea that there was nothing actually wrong with her.

“I needed treatment, not someone telling me it’s going to be fine,” she continued. By the time they diagnosed her cancer, she had three tumors in her lungs, the biggest one the size of a lime.

Lucas didn’t cry then. “Honestly, I felt relief, because battling insurance and trying to even get that diagnosis was the worst part,” she said.

In many ways, it’s not surprising that Cheng, Gomez and Shum — three Asian American women — are leading the first-of-a-kind studies, because who else would be motivated enough to jump through all the hoops and push through the skepticism?

“It’s been a very personal matter for us,” Cheng said. “As Asian Americans ourselves, we see this in our community. It just adds another aspect of us being dedicated to bring attention to this inequity.”

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This article was originally published on NBCNews.com



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